Endocrine Abstracts

Aim: Egypt is among the world’s top 10 countries in terms of the highest number of people with diabetes. Charcot foot is a serious complication that affect bones, joints, and soft tissues of the foot or ankle. Although the etiology is linked to different inflammatory markers, yet not clear. Recently, an association between two polymorphisms (1181G > C and 245T > G) of the osteoprotegerin (OPG) gene and Charcot was suggested. The aim of this study was to explore p...

Introduction: Follicle-stimulating hormone (FSH) is a glycoprotein that support reproduction by regulating ovarian follicular growth and development. Recent studies demonstrated that proliferative signals mediating folliculogenesis are mediated by the G protein-coupled estrogen receptor (GPER) expressed in ovarian tissues throughout the follicular phase. In granulosa cells, GPER forms heteromers with FSHR, reprogramming cAMP-induced death signals to AKT-dependent, anti-apoptot...

During the menstrual cycle, selection of the dominant follicle is characterized by changes of gonadotropin and steroid hormone receptor expression. We aim to evaluate whether co-existing follicle-stimulating hormone receptor (FSHR) and G protein-coupled estrogen receptor (GPER) form heterodimers, suggesting their role in ovarian follicle selection. FSHR-GPER dimerization was evaluated in transfected HEK293 cells in vitro by bioluminescence resonance energy transfer (B...

Introduction: The developmental stages of the ovarian follicle are characterized by changes of gonadotropin and steroid hormone receptor expression and their potential interactions on the surface of granulosa cells. In this study in vitro, we aim to evaluate whether the co-existing follicle-stimulating hormone receptor (FSHR) and G protein-coupled estrogen receptor (GPER) form heteromers, which may play role in selecting the dominant ovarian follicle.<p class="abs...

The anorectic gut hormones glucagon-like peptide-1 (GLP-1) and Peptide YY (PYY) are secreted by enteroendocrine L cells in response to short chain fatty acids (SCFAs) produced by gut microbiota following dietary fibre consumption. SCFAs, acetate, propionate and butyrate, activate the G protein-coupled receptors Free Fatty Acid Receptor 2 and 3 (FFAR2, FFAR3). Increasing intestinal levels of propionate can prevent weight gain in overweight adults. In rodents, FFAR2-mediated gut...

Introduction: Type 1 Gastric neuroendocrine tumors account for 70 to 80 percent of all gastric neuroendocrine tumors (G-NETs) and they are found more commonly in older adults, particularly women. They are associated with autoimmune metaplastic atrophic gastritis (AMAG) with or without pernicious anemia. Endoscopically, they are usually smaller than 1 cm and often multiple. These tumors usually present a non-aggressive evolution. Our goal is to approach the presence of risk fac...

IntroductionWomen with Turner Syndrome (TS), characterised by the complete or partial absence of one X-chromosome in females, are reported to have an increased risk of coeliac disease, inflammatory bowel disease and angiodysplasia. These may contribute to iron deficiency and anaemia through malabsorption or blood loss. This study screened the serum ferritin and haemoglobin measurements in an adult TS population.MethodSerum ferritin concentrations were measured in 1...

Fetal exposure to environmental estrogens may contribute to hypofertility and/or to testicular germ cell cancer. However, many of these endocrine disruptors have only a weak affinity for the classical ERs and other mechanisms have been suggested. Bisphenol A, a chemical poluttant, used as monomer to manufacture polycarbonate plastic, released from lining canned food or beverages or from dental sealants, was able to promote human testicular seminoma cell (JKT-1) proliferation <...

G R Williams, Imperial College London, London, UK. AbstractGraham R Williams obtained a BSc in Anatomy and MBBS from St Thomas’s Hospital, London and undertook PhD studies in Molecular Endocrinology at Birmingham University. He trained as a Howard Hughes and MRC Fellow at Harvard Medical School, USA and was an MRC Clinician Scientist Fellow in Birmingham. He was appointed Senior Lecturer at the Royal Postgraduate...

Desmond G Johnston, Campus Dean, St Mary’s Hospital Campus, Imperial College London, London, UK Director, UK Diabetes Research Network AbstractProfessor Johnston trained in Edinburgh and Southampton where, as an MRC Training Fellow, he did his PhD with Professor George Alberti. His work at that time investigated metabolic disturbances in liver disease and metabolic aspects of endocrinology.I...